Rui Xiao


Professor, Principle Investigator

Medical Research Institute, Wuhan University



    Rui Xiao, PhD


1999-2003: B.A. in Biotechnology,

College of Life Sciences, Wuhan University, China  

2004-2010: PhD in Biochemistry and Molecular Biology,

College of Life Sciences, Wuhan University, China  


Professional Experience:

2011-2017: Postdoctoral Researcher,

  Department of Cellular and Molecular Medicine, UC San Diego, USA

2017-Now: Professor, Medical Research Institute, Wuhan University, China

2020-Now: PI, Frontier Science Center for Immunology and Metabolism, Wuhan University, China


Research Interests:

RNA Biology and Functional Genomics



1. Ren, F., Miao, R., Xiao, R.*, Mei, J.* (2021) m6A reader Igf2bp3 enables germ plasm assembly by m6A-dependent regulation of gene expression in zebrafish. Science Bulletin (in press)

2. Du, X., Xiao, R.* (2020) An emerging role of chromatin-interacting RNA-binding proteins in transcription regulation. Essays in Biochemistry. 64 (6): 907–918.

3. Van Nostrand, E.#, Freese, P.#, Pratt, G.#, Wang, X.#, Wei, X.#, Xiao, R.#, Blue, S., Chen, J., Cody, N., Dominguez, D., Olson, S., Sundararaman, B, Zhan, L., Bazile, C., Bouvrette, L., Bergalet, J., Duff, M., Garcia, K., Gelboin-Burkhart, C., Hochman, M., Lambert, N., Li, H., Nguyen, T., Palden, T., Rabano, I., Sathe, S., Stanton, R., Su, A., Wang, R., Yee, B., Zhou, B., Louie, A., Aigner, S., Fu, XD*, Lécuyer, E.*, Burge, C.*, Graveley, B.*, Yeo, G.* (2020) A Large-Scale Binding and Functional Map of Human RNA Binding Proteins. Nature. 583: 711-719.

4. The ENCODE Project Consortium et al. (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 583, 699–710.

5. The ENCODE Project Consortium et al. (2020) Perspectives on ENCODE. Nature. 583, 693–698.

6. Li, Y., Xia, L., Tan, K., Ye, X., Zou, Z., Li, M., Xiao, R., Wang, Z., Liu, X., Deng, M., Cui, J., Yang, M., Luo, Q., Liu, S., Cao, X., Zhu, H., Liu, T., Hu, J., Shi, J., Xiao, S.*, Xia, L.*(2020) N(6)-methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2. Nature Genetics. 52, 870-877.

7. Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.*, Mei, J.* (2020). Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebra?sh. Communications Biology. 3, 94.

8. Xiao, R.#*, Chen, JY#, Liang, Z#, Luo, D., Chen, G., Lu, Z., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lecuyer, E., Graveley, B., Yeo, G., Burge, C., Zhang, M., Zhou, Y. and Fu, XD* (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription. Cell. 178(1):107-121.

9. Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., and Fu, XD (2017) R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters. Molecular Cell. 68(4): 745-57.

10. Wei, C.#, Xiao, R.#, Chen, L.#, Cui, H.#, Zhou, Y.#, Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L. and Fu, XD (2016) RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell. 62(6):875-889.

11. Wang, L.#, Zhou, Y.#, Xu, L.#, Xiao, R.#, Lu, X., Chen, L., Chong, J., He, C., Fu, XD and Wang, D. (2015) Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 523(7562):621-625.

12. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B. and Fu, XD (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 153(4):855-68.

13. Xiao, R.#, Tang, P.#, Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. and Fu, XD* (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell. 45(5):656-668.




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